A 2007 third-round draft pick, Mebane played for the Seahawks and started 10 games his rookie season. Mebane spent the first four seasons of his career playing at left defensive tackle and then was moved over to right defensive tackle for the next five seasons. He played in 131 games, recorded 15.5 sacks and 349 tackles. He was part of the Super Bowl XLVIII team, providing veteran leadership on a young defense.